How I Travel with BLANK!
Ahhh, a nice relaxing vacation - doesn't that sound great?! Or maybe you're into the outdoors and adventure? Wherever your dream destination, we all know there's one thing that can be tough about traveling... no, not booking plane tickets, or the flight itself... I'm talking about PACKING!
Over the years I've become a better "packer" - not the best, but better. I used to be someone who would bring the largest suitcase allowed, fill it with every possible outfit option (what if it rains, what if it snows, what if it's colder than I anticipate, or hotter - GAH!)... and then end up wearing the same 3 things. I made a commitment to myself to be better about traveling light... er.
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carnosine (beta-alanyl-l-histidine) is a dipeptide molecule, made up of the amino acids beta-alanine and histidine. it is highly concentrated in muscle and brain tissues.
carnosine and carnitine were discovered by russian chemist vladimir gulevich. it has been proven to scavenge reactive oxygen species (ros) as well as alpha-beta unsaturated aldehydes formed from peroxidation of cell membrane fatty acids during oxidative stress. it also buffers ph in muscle cells, and acts as a neurotransmitter in the brain. it is also a zwitterion, a neutral molecule with a positive and negative end.
like carnitine, carnosine is composed of the root word carn, meaning “flesh”, alluding to its prevalence in animal protein. there are no plant-based sources of carnosine. therefore, a vegetarian or vegan diet provides little or no carnosine in comparison to the amounts found in a diet that includes meat.
carnosine can chelate divalent metal ions.
carnosine can increase the hayflick limit in human fibroblasts, as well as appearing to reduce the telomere shortening rate. it is also considered as a geroprotector.
carnosine is synthesized in vivo from beta-alanine and histidine. since beta-alanine is the limiting substrate, supplementing just beta-alanine effectively increases the intramuscular concentration of carnosine.
carnosine has a pka value of 6.83, making it a good buffer for the ph range of animal muscles. since beta-alanine is not incorporated into proteins, carnosine can be stored at relatively high concentrations (millimolar). occurring at 17–25 mmol/kg (dry muscle), carnosine (ß-alanyl-l-histidine) is an important intramuscular buffer, constituting 10-20% of the total buffering capacity in type i and ii muscle fibres.
, sold under the brand name cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by gram-positive organisms. it is a naturally occurring compound found in the soil saprotroph streptomyces roseosporus. its distinct mechanism of action makes it useful in treating infections caused by multiple drug-resistant bacteria.
daptomycin was removed from the world health organization’s list of essential medicines in 2019. the world health organization classifies daptomycin as critically important for human medicine.
daptomycin is indicated for use in adults in the united states for skin and skin structure infections caused by gram-positive infections, s. aureus bacteraemia, and right-sided s. aureus endocarditis. it binds avidly to pulmonary surfactant, so cannot be used in the treatment of pneumonia. there seems to be a difference in working daptomycin on hematogenous pneumonia.
common adverse drug reactions associated with daptomycin therapy include:
cardiovascular: low blood pressure, high blood pressure, swelling
central nervous system: insomnia
gastrointestinal: diarrhea, abdominal pain
other: injection site reactions, fever, hypersensitivity
less common, but serious adverse events reported in the literature include
hepatotoxicity: elevated transaminases
nephrotoxicity: acute kidney injury from rhabdomyolysis
also, myopathy and rhabdomyolysis have been reported in patients simultaneously taking statins, but whether this is due entirely to the statin or whether daptomycin potentiates this effect is unknown. due to the limited data available, the manufacturer recommends that statins be temporarily discontinued while the patient is receiving daptomycin therapy. creatine kinase levels are usually checked regularly while individuals undergo daptomycin therapy.
in july 2010, the fda issued a warning that daptomycin could cause life-threatening eosinophilic pneumonia. the fda said it had identified seven confirmed cases of eosinophilic pneumonia between 2004 and 2010 and an additional 36 possible cases. the seven confirmed victims were all older than 60 and symptoms appeared within two weeks of initiation of therapy.
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